Freight handlers Wilbur Grey and Chick Young's world is disrupted when the remains of Frankenstein's monster and Dracula arrive in a house of horrors. Dracula escapes and plans to reanimate the monster with a new brain, while the Wolfman, Larry Talbot, tries to stop him.

Abbott and Costello Meet Frankenstein
The Wolf Man attempts to alert a portly porter to Dracula's plan to transplant Frankenstein's monster's brain into his own head.