In the futuristic city of Kamina City, a young prostitute named Rune Ballot is taken in by the notorious gambler Shell Septinous. But after being abandoned and left for dead in an explosion, Rune is rescued and transformed into a cyborg by Dr. Easter. With the help of an AI mouse, Rune learns to harness her new advanced technology to defend herself against Shell's deadly attempts to silence her.

Mardock Scramble: The Third Exhaust
In the bustling city of Kamina, a young sex worker named Rune is unexpectedly rescued by Shell, a cunning gambler. However, their reunion takes a dark turn as Shell abruptly leaves Rune to face a devastating explosion alone.