Amy Seimetz first gained recognition in the film industry by producing and directing short and independent films. One of her most notable projects was associate producing Barry Jenkins' Medicine For Melancholy, which received nominations for Gotham and Independent Spirit Awards and premiered at the South By Southwest and Toronto International Film Festival.
She then transitioned to acting, earning recognition for her performance in Joe Swanberg's Alexander The Last, a film produced by Noah Baumbach and premiered at SXSW. This marked the beginning of a successful collaboration with Joe Swanberg, with whom she would go on to work on three films, including Silver Bullets, Autoerotic, and Gabi On The Roof In July.
Seimetz continued to impress audiences with her indie performances in Lawrence Levine's Gabi On The Roof In July, Lena Dunham's Tiny Furniture, Kentucker Audley's Open Five, and David Robert Mitchell's Myth of the American Sleepover, which premiered at the Cannes Film Festival.
Her performance in Adam Wingard's A Horrible Way To Die earned her the Best Actress award at Fantastic Fest, the largest genre film festival in the US. The film received rave reviews after its premiere at the Toronto International Film Festival.
Seimetz is perhaps most well-known for her performance in Megan Griffiths' drama The Off-Hours, which premiered at the Sundance Film Festival in 2011. The Hollywood Reporter highlighted her as one of the breakout stars of the festival that year, alongside Brit Marling, Elizabeth Olsen, and Felicity Jones.
She then appeared in the Tribeca Film Festival premiere Revenge For Jolly, an ensemble cast film directed by Chadd Harbold, alongside Kristen Wiig, Elijah Wood, Oscar Isaac, Garrett Dillahunt, Ryan Phillippe, Gillian Jacobs, Adam Brody, and Brian Petsos. The film marked a reunion for Seimetz with her co-stars Wiig, Dillahunt, and Petsos from the Chadd Harbold short film One Night Only.
In 2012, Seimetz made her narrative feature directorial debut with her Floridian thriller Sun Don't Shine, which she also wrote, produced, and co-edited. The film premiered at the South By Southwest Film Festival in the Emerging Visions section to rave reviews.