Chloë's early life was marked by her upbringing in the vibrant city of London, where she had the opportunity to attend the esteemed Mountview Theatre School. Initially, she had intended to pursue a career in the arts at an art school, but a serendipitous turn of events led her to attend an audition with a friend, which ultimately secured her a spot at the theatre school. Chloë has credited her parents with being incredibly supportive of her decision to switch career paths, and has expressed gratitude for their unwavering encouragement. Her father, Paul Annett, is a renowned director who has undoubtedly played a significant role in shaping her artistic endeavors.
Chloë's professional journey has taken her to various corners of the globe, including America, where she secured a role in the TV mini-series "Jewels" in 1992. However, it was her breakout role as Kristine Kochanski in the popular sci-fi comedy series "Red Dwarf" in 1997 that catapulted her to stardom. This pivotal moment in her career was swiftly followed by her portrayal of Holly Turner in the crime drama "Crime Traveller" alongside Michael French, who played the character of Jeff Slade.