Francesca Dellera's journey began with her high school diploma, which marked the starting point of her illustrious career as a model. Her remarkable physical beauty led to her image being featured on the covers of national and international publications, with some of the most renowned photographers of the time capturing her portrait, including Helmut Newton, Dominique Isserman, Greg Gorman, Michael Comte, Andre Rau, and many others.
As her modeling career continued to flourish, the film industry took notice of her exceptional talent, and she made her screen debut in Tinto Brass's movie Capriccio (Love & Passion). She also appeared in the 3-part TV miniseries La Romana, directed by Giuseppe Patroni Griffi, and the television adaptation of the film of the same name, directed by Luigi Zampa in 1954, which was based on the novel by Alberto Moravia.
Her breakthrough role came with the movie La Carne, directed by Marco Ferreri, which earned her international recognition and acclaim. Her success continued to grow in France, where she worked alongside international stars such as Alain Delon in L'Ours en peluche, directed by Jacques Deray. She soon became a favourite model of the renowned fashion designer Jean Paul Gaultier.
After spending several years in France, Dellera returned to Rome to star in the lead role of Nanà, a 2-part television miniseries directed by Alberto Negrin, which was an adaptation of the novel of the same name by Émile Zola. She also appeared in the television movie La Contessa di Castiglione, co-produced with a French television production company, directed by Josée Dayan, alongside Sergio Rubini and Jeanne Moreau.
In addition to her work in film and television, Dellera has made a significant impact in the world of advertising. She was recognized for her outstanding work in the best advert of the year, directed by Maurizio Nichetti for "IP". She has also been the testimonial in several other successful campaigns for famous brands, cementing her status as a highly sought-after model and actress.