Katrina Bowden was born on September 19, 1988, and grew up in Wyckoff, New Jersey. She attended Saint Thomas More School in Midland Park, New Jersey, for her grammar and middle school education, before moving on to Immaculate Heart Academy in Washington Township, New Jersey.
Bowden's acting career began in 2006 with a two-episode arc on the ABC soap opera One Life to Live, followed by guest appearances on Law & Order: Special Victims Unit and Ugly Betty. Her breakthrough role came when she was cast as Cerie on the Emmy Award-winning comedy series 30 Rock, a position she held from 2006 to 2013.
Bowden made her film debut in the raunchy comedy Sex Drive in 2008, and went on to star in two low-budget straight-to-DVD projects, The Shortcut and National Lampoon's Ratko: The Dictator's Son, in 2009. In 2010, she starred in the critically acclaimed horror-comedy Tucker and Dale vs Evil, which premiered at the Sundance Film Festival.
In 2011, Bowden was voted Esquire Magazine's Sexiest Woman Alive and became the face of the Jordache television campaign. She appeared in Piranha 3DD and Hold Your Breath in 2012, before co-starring in Nurse in 2013.
In her personal life, Bowden became engaged to musician Ben Jorgensen in 2012, and the couple married on May 19, 2013, in the Brooklyn Botanical Garden in New York.