Kelly, originally from Bloomington, Minnesota, embarked on her educational journey at the Academy of Holy Angels in Richfield, Minnesota. Born to a hair dresser mother and a late father who was a high school basketball coach, Kelly's upbringing played a significant role in shaping her future endeavors. Prior to venturing into the world of screen performances, Kelly began her acting career in theater, gradually transitioning to television and film.
Kelly's early appearances on screen include a minor role in 3000 Miles to Graceland (2001) and a notable television role on the series Nip/Tuck (2003),which catapulted her to fame. Her character's popularity eventually led to her becoming a regular cast member. Kelly's feature film credits include supporting roles in the direct-to-video sequel Starship Troopers 2: Hero of the Federation (2004) and the WWE-produced action film The Marine (2006),where she played the kidnapped wife of wrestling star John Cena.
Throughout her career, Kelly has established a diverse portfolio of work in television, appearing in a range of series, including Everwood (2002),Monk (2002),CSI: Crime Scene Investigation (2000),Melrose Place (2009),CSI: Miami (2002),Castle (2009),Supernatural (2005),and Ghostfacers (2008).
Outside of her acting career, Kelly is a dedicated member of the Smile Network, a humanitarian organization based in her home state that provides reconstructive surgeries and related healthcare services to impoverished children and young adults in developing countries. In 2010, Kelly used her platform to advocate for a bill aimed at preventing the inhumane transport of American horses to slaughterhouses in Mexico and Canada, as well as government-sponsored roundups of wild horses.
In addition to her acting and humanitarian work, Kelly has also pursued a career in modeling, collaborating with companies such as Miller Lite, Rembrandt, and Oliver Peoples sunglasses. Her magazine credits include the August 2004 issue of Maxim and the October issue cover of Stuff.