Kristina Asmus was born Kristina Igorevna Myasnikova on April 14, 1988, in Kaliningrad, Moscow region, RSFSR, USSR, which is now known as Korolev, Russia. As a child, she was involved in gymnastics, becoming a Candidate for Master of Sports.
In her teenage years, while still in high school, she played the role of Zhenya Komelkova in a theatrical adaptation, directed by Elena Makhona, of Boris Vasilev's novel "A zori zdes tikhie..." ("The Dawns Here Are Quiet...") at the director's theater "Makhona ELena" ("MEL") in Moscow. After graduating from high school, she played the role of Fantine in Ivan Elagin's play "Portret madmuazel Tarzhi" ("The Portrait of Mademoiselle Tarsi") and the title role of the dog Silviya in the play "Silviya", a Russian adaptation of American playwright A.R. Gurney's play "Sylvia", both directed by Nataliya Ermakova of the "Korolevskiy Teatr Yunogo Eritelya" ("The Royal Theater for a Young Audience") at the "Teatr Dobroy Skazki" ("The Theater of the Kind Fairy Tale") in Moscow.
Before pursuing a career in acting, she worked in the modeling business during her late teenage years.
In 2008, she enrolled in the Mikhail Shchepkin Higher Theater School, graduating in 2012 under the guidance of renowned Soviet-era actor Boris Klyuev.
Her screen debut occurred in early 2010, when she played the role of Varvara Chernous in director Maksim Pezhemskiy's popular comedy series Interny (2010) ("Interns").
Later that year, in late 2010, she was named the Sexiest Woman of the Year in the Russian edition of Maxim magazine, appearing on the cover that October, with a full pictorial and interview inside.
In 2011, she starred in the role of Sasha in the detective story 'Alibi' na dvoikh (2011) ("An 'Alibi' for Two"),directed by Nikolay Gusev.
Kristina Asmus currently resides in Moscow with her husband, actor and comedian Garik Kharlamov, and their daughter Anistasiya.