Brice, a highly educated individual, earned his degree in mining engineering after completing his studies at Columbia University. His academic achievements led to a career opportunity as a sales manager for the Texas Oil Company, which was headquartered in New York. However, it seems that this endeavor did not work out in the long run, as Brice eventually found himself in Hollywood, pursuing a new path as a small part actor in comedies starring Pearl White between 1913 and 1914.
After a several-year hiatus, during which he focused on other business ventures, Brice returned to the film industry in 1921, this time as a screenwriter. He continued to grow as a creative force, diversifying his talents by directing one- and two-reel shorts for Paramount Pictures from 1927 to 1930, occasionally taking on the role of producer as well. Notably, Brice directed W.C. Fields in his first talkie, the classic two-reel farce The Golf Specialist, released in 1930.
Following his departure from Paramount, Brice focused primarily on screenwriting and creating original scenarios for feature films, either solo or in collaboration with others. He later became a member of Bob Hope's team of gag writers, showcasing his versatility and talent in the world of comedy. Throughout his career, Brice was married to Doris Hill, a former vaudeville dancer and actress whom he had previously directed in Casey at the Bat, a 1927 film.