Sergio Castellitto was born in Rome, Italy in 1953. He began his theatrical career after graduating from the Silvio D'Amico National Academy of Dramatic Art in 1978, performing in various plays including "Measure for Measure", "La Madre", "The Merchant of Venice", and "Candelaio". He worked alongside notable actors such as Luigi Squarzina, Aldo Trionfo, and Enzo Muzii.
Castellitto's film career started in 1983 with "The General of the Dead Army" alongside Marcello Mastroianni and Michel Piccoli. He went on to star in numerous films, including "Sembra morto...ma è solo svenuto", "Piccoli equivoci", and "Stasera a casa di Alice". He gained recognition with films like "The Great Pumpkin" and "The Star Maker".
In the late 1980s, Castellitto appeared in several Italian television miniseries, including "Un siciliano in Sicilia", "Cinque storie inquietanti", and "Piazza Navona". He also appeared in the miniseries "Victoire, ou la douleur des femmes" in 2000.
Castellitto's success came with films like "La famiglia", "L'ultimo bacio", "Caterina in the Big City", "My Mother's Smile", "Mostly Martha", and "Don't Move", which was written by his wife Margaret Mazzantini. He has also appeared in films such as "Il regista di matrimoni" and "La stella che non c'è".
In France, Castellitto played the male lead in Jacques Rivette's "Va savoir" opposite Jeanne Balibar in 2001. His most notable role was as "Padre Pio: Miracle Man", which is arguably the defining role of his career.
Castellitto has also directed several films, including "Libero Burro" and "Don't Move". He played the role of King Miraz in the film "The Chronicles of Narnia: Prince Caspian". His most recent film as director was "Twice Born", which premiered at the Toronto Film Festival in 2012.
Castellitto has appeared in the television series "In Treatment" in the role of Giovanni. He is married to Margaret Mazzantini and has four children.