Santos's on-screen career began with a notable featured role in the South African drama "Ayeye", a production of The Bomb Shelter, marking the initial step in her journey as an actress.
In 2015, she made a significant film appearance in the independently produced "Free State", starring alongside a talented ensemble cast that included Nicola Breytenbach, Andrew Govender, Leleti Khumalo, and Deon Lotz, with the direction of Salmon de Jager.
This was followed by her first lead role in the critically acclaimed post-apocalyptic film "Last Broken Darkness", where she took on the pivotal role of 'Rose', a performance that showcased her versatility and range as an actress. The film was written and directed by Christopher-Lee Dos Santos, and also starred Sean Cameron Michael and Brandon Auret.
The film premiered at the esteemed Sun Filmscreen Festival in St Petersburg, Florida in the early months of 2017, where Santos was honored with an invitation to participate in the esteemed 'Women in Film & Voice' Workshop panel, alongside an array of notable industry professionals, including Daphne Zuniga, Edy Ganem, Selenis Leyva, and producers Jennifer Gelfer and Thada Catalon.
In addition to her extensive film work, Santos has made cameo appearances in the South African films "The Jakes are Missing", a production of FigJam Productions, and "Looking for Love", directed by the acclaimed Adze Ugah.
Furthermore, Santos has also made a notable appearance in an episode of the American television series "ICE", alongside the talented Cam Gigante and Jeremy Sisto.