Final Fantasy VII: Advent Children

A disease called 'Geostigma' is spreading across the planet, believed to be a result of the body fighting off foreign material from two years earlier. Cloud Strife, haunted by his past, lives a solitary life and runs a delivery service while Tifa Lockhart's bar serves as an orphanage for Geostigma-stricken children. Cloud receives a call from Rufus, former Shinra president, seeking protection from Kadaj, a mysterious man searching for his "mother" with his brothers Loz and Yazoo.