Ash, Misty, and Brock continue their adventure in the Johto region, only to find Pikachu kidnapped by Team Rocket.

Pokémon: Mewtwo Returns
Team Rocket's memories of Mewtwo were wiped clean, but the scientists' records remained intact. In their relentless pursuit of the truth, they managed to track down Mewtwo's location and establish a covert base in Johto. Coincidentally, Ash and his friends had their first encounter...