Carl Fredricksen, a boy with a lifelong dream, finally embarks on an adventure to explore South America and find the elusive Paradise Falls, accompanied by Boy Scout Russell, after lifting his house with thousands of balloons. Along the way, they befriend a talking dog and uncover a sinister plot, only to discover that the mastermind is none other than Carl's childhood hero.

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An elderly explorer sets out on a heart-pumping quest to reach the breathtaking Paradise Falls, alongside an unlikely travel companion.