Tommy Nelson, a boxer, is accused of murdering his manager. As detectives Bud and Lou investigate, they stumble upon an invisibility formula that Tommy uses to evade capture. Inspired by this discovery, they concoct a plan to catch gangster Morgan by having Lou compete against Rocky Hanlon, with Tommy's invisible assistance.

Bud Abbott and Lou Costello Meet the Invisible Man
Two unlikely detectives join forces to solve a complex case, unraveling the mystery of an accused killer who has seemingly vanished into thin air.