Dr. Charlie Logan, a dentist in his thirties, has never experienced true love despite having many girlfriends. After his reputation as a good-luck charm spreads, he's encouraged by his friend Dr. Stu Klaminsky to exploit it. Charlie wants to find true love, not just be a stepping stone for women. He's drawn to accident-prone Cam Wexler, who works at the aquarium, but she's hesitant to date him due to his reputation. Charlie's quest for true love takes an unexpected turn with the help of Anisha Carpenter.

Good Luck Chuck
A charismatic individual, enchanted with an unrelenting allure, embarks on a quest to shatter the curse before his beloved falls prey to another's affections.