Two old friends, Cheech and Chong, stumble upon each other on a California highway and embark on a journey to find some marijuana. After a series of events, they find themselves accidentally deported to Mexico, where they agree to drive a mysterious van back to the States to make it to an upcoming gig. Along the way, they pick up two female hitchhikers and try to evade the police, who are hot on their tail.

Up in Smoke
Carefree friends accidentally transport a van full of marijuana from Mexico to Los Angeles, sparking a chaotic pursuit by a hapless Sergeant Stedenko.