Clayton Pierce, a top agent, questions his loyalty after 20 years of service, which has already cost him his personal life. After a de-briefing, he's unknowingly given Oblivion, a drug causing permanent memory loss. Clayton must find the antidote before it's too late, turning to his ex-wife Kate for help.
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A skilled operative is given a mysterious substance that erases his recollections, giving him a limited window of 48 hours to rediscover his true identity and outsmart a deadly trap.