Dana DeLorenzo was born and raised in Youngstown, Ohio, where she developed a natural affinity for comedy and performance at a tender age. At just three years old, she began crafting knock-knock jokes and recording them on her Fischer-Price tape recorder, solely to relive the laughter and joy she experienced while creating them. As she grew older, DeLorenzo's talent for impressions blossomed, and she landed her first paid gig at the age of 11, performing a rendition of Abbott and Costello's classic routine "Who's On First" alongside her younger brother in a weekly variety show.
After graduating from DePaul University in Chicago, DeLorenzo pursued a career in broadcasting, becoming an on-air personality and producer on The Mancow Show. Concurrently, she continued to hone her craft through various theater productions around the city. In 2008, she formed an Amy Winehouse tribute band called House of Winehouse, which performed at numerous festivals and venues, including Pridefest Milwaukee and House of Blues Chicago. DeLorenzo's uncanny portrayal of the singer earned international acclaim, including a feature in The Chicago Tribune and a Best Tribute Band award from The Chicago Reader in 2010.
Later that year, DeLorenzo relocated to Los Angeles, where she began to make a name for herself in the entertainment industry. She appeared in a range of TV shows, including Californication, Workaholics, and 2 Broke Girls, as well as films such as A Very Harold and Kumar 3D Christmas and The Mad Ones. DeLorenzo's breakthrough role came when she was cast alongside Bruce Campbell in the horror-comedy series Ash Vs. Evil Dead, a continuation of the cult-classic movie trilogy The Evil Dead written and directed by Sam Raimi. As Kelly Maxwell, the foul-mouthed demon-slaying sidekick to the show's titular anti-hero, DeLorenzo won the approval of fans and critics alike, earning back-to-back nominations for a Fangoria Chainsaw Award and an iHorror Award nomination for Best Actress in a Horror Series.
In 2018, DeLorenzo received the Artemis Women in Action Next Wave award, solidifying her status as a talented and versatile performer. Since wrapping the final season of Ash Vs. Evil Dead, DeLorenzo has continued to impress audiences with her versatility, landing guest-starring roles on the reboot of Will & Grace and the critically-acclaimed series Perpetual Grace, LTD., as well as a recurring role on the female-driven comedy Friendsgiving. DeLorenzo has also lent her vocal talents to various animated projects, including Teenage Mutant Ninja Turtles, King Tweety, and the Netflix animated children's series, Ask The StoryBots.