Frank Grillo, the eldest of three siblings, was born within the five boroughs of New York City to a family of Italian-American descent. His formative years were spent in the upstate region of New York, where he developed a strong foundation for his future endeavors.
Grillo's introduction to the world of acting occurred during his high school years, where he actively participated in numerous plays, showcasing his nascent talent. Concurrently, he also demonstrated exceptional athletic prowess, with a dream of pursuing a professional sports career.
Upon completing his education, Frank Grillo earned a business degree from New York University, providing him with a solid foundation in the business world.