Frank Wolff's acting career began with roles in several films produced by Roger Corman, but he found greater success in Europe, particularly in Italy, following his performance in Salvatore Giuliano in 1962.
He went on to have numerous roles in various European film productions, solidifying his reputation as a talented actor.
Wolff's performances in Spaghetti Westerns catapulted him to stardom, with his most notable and brief role being that of Brett McBain, a friendly farmer, in Sergio Leone's Once Upon a Time in the West in 1968.
He also brought much-needed comic relief to his role as the sheriff in Sergio Corbucci's The Great Silence in 1968.
As the era of Spaghetti Westerns came to a close, Wolff transitioned to roles in Italian crime movies, delivering memorable performances in Duccio Tessari's Giallo Death Occurred Last Night in 1970 and Fernando Di Leo's Caliber 9 in 1972.
Tragically, the talented actor struggled with depression and took his own life in the Hilton Hotel in Rome in December 1971.