Humphrey Ker's educational background began at Eton College, where he later transitioned to Edinburgh University on a military scholarship. However, after feeling disillusioned with the base he would be training at and deciding that comedy was more enjoyable, he abandoned his potential military career.
During his time at Edinburgh University, Ker studied history and became a member of the esteemed comedy group, "The Improverts." It was here that he met David Reed and Thom Tuck, and together they formed the Victorian comedy sketch troupe, "The Penny Dreadfuls." The trio showcased their talents at the Edinburgh Fringe Festival, as well as writing and performing in two radio series for the BBC, "The Brothers Faversham" and "More Brothers Faversham."
In 2010, "The Penny Dreadfuls" decided to take a hiatus, and Ker opted to create his own show at the Edinburgh Festival in 2011. His show, "Dymock Watson: Nazi Smasher," was loosely based on the history of his maternal grandfather, Vice-Admiral Sir Dymock Watson. Ker's outstanding performance earned him the Fosters Best Newcomer Comedy Award.
On screen, Ker has appeared in various sketch shows, including the BBC's "Fast and Loose" and CBBC's "Fit." Although "The Penny Dreadfuls" are currently on hiatus, Ker and his fellow Dreadfuls continue to create and perform in one-off specials for BBC Radio 4, titled "Penny Dreadfuls Presents." He has also appeared on several panel shows on the station and acted as the curator for the 6th series of "The Museum of Curiosity."
As of 2013, Ker is developing his sitcom, "Terrible People," for the US ABC network.