Virginia Grey's journey in the entertainment industry began at the tender age of 10, when she made her film debut as Eva in the 1927 adaptation of Uncle Tom's Cabin. Prior to this, she had already appeared in a few films as a child actress, but she soon took a hiatus to focus on her education. Years later, she returned to the film industry as a young adult in the 1930s, initially securing extra work and small parts, before gradually transitioning to speaking roles and eventually landing a contract with MGM.
Under the studio's wing, Grey was cast in leading roles in "B" pictures and supporting roles in "A" pictures, solidifying her status as a talented and versatile actress. However, she decided to part ways with MGM in 1942 and embarked on a solo career, working with almost every major studio in Hollywood. Throughout her illustrious career, Grey continued to work consistently in both film and television, eventually retiring from the industry in 1970.