A scientist, Dr. Elsa Reinhardt, creates a hybrid monstrosity by crossing the genes of a killer whale and a wolf, unleashing the uncontrollable whalewolf. Meanwhile, an alcoholic boat captain and his partner search for a sharktopus roaming free in the Dominican Republic, but their quest is disrupted when the whalewolf wreaks havoc on land.

Sharktopus vs. Whalewolf
As a genetically modified sea monster, the Whalewolf wreaks havoc on the coast, prompting Sharktopus to take drastic measures to restore balance to the ocean.