In Hawaii, Sean Jones witnesses a powerful mobster's brutal murder of an American prosecutor. FBI agent Neville Flynn convinces Sean to testify against the mobster in Los Angeles, and they board a red-eye flight. However, the mobster unleashes hundreds of snakes on the plane, causing chaos and danger for the passengers and Neville as they fight to survive.

Snakes on a Plane
A high-stakes mission unfolds as a skilled agent battles against the clock to prevent a catastrophic plot from unfolding, involving a sinister plan to release a plane carrying a cargo of venomous snakes, putting a crucial witness on a flight from Honolulu to Los Angeles in grave danger.