A group of nerdy friends, led by Lewis, attend the wedding of Booger to a wealthy Republican's daughter, but the event is threatened by hostile family members who object to the union. As Lewis awaits the arrival of his unborn child, he and his friends face various obstacles in their pursuit of happiness.

Revenge of the Nerds IV: Nerds in Love
Before his wedding, a groom's quirky reputation is challenged as his fiancé's father and friends work to dispel misconceptions about his nerdy persona.