Elisabeth Shue was born in Wilmington, Delaware, to Anne Brewster (Wells),a dedicated employee of the Chemical Banking Corporation, and James William Shue, a lawyer and real estate developer, who together shared a rich ancestry comprising German and English roots, with a notable connection to the Mayflower passengers. Tragedy struck early in Shue's life when her parents divorced while she was still in the fourth grade, forcing her and her siblings to navigate the challenges of growing up in a suburban neighborhood with parents who were often away due to their demanding careers.
Despite the difficulties, Shue found solace in her studies and enrolled in Wellesley College, an all-female institution that provided a sense of stability and structure. However, she soon discovered a way to supplement her income by acting in television commercials, becoming a familiar face in ads for prominent brands such as Burger King, DeBeers diamonds, and Hellman's mayonnaise.
In 1984, Shue landed a significant role in the film The Karate Kid, playing the on-screen girlfriend of Ralph Macchio, and also appeared in the short-lived series Call to Glory, portraying the teenage daughter of a military family. Around this time, she began studying political science at Harvard, where she also worked with an acting coach to hone her craft.
Shue's early career was marked by a string of successful films, including Adventures in Babysitting, Cocktail, Soapdish, and The Marrying Man. However, her brother Andrew Shue's rising fame on the hit TV series Melrose Place (1992) may have overshadowed her own accomplishments at the time.
It was during this period that Shue took a calculated risk by starring in the low-budget, high-risk project Leaving Las Vegas (1995),directed by Mike Figgis. Her courageous portrayal of a prostitute struggling with addiction earned her a Best Actress nomination at the Academy Awards, marking a turning point in her career.
Following this critical success, Shue went on to appear in a diverse range of films, including The Saint, Deconstructing Harry, Palmetto, and Hollow Man.