Margaret McWade, a talented actress, was born Margaret May Fish in the vibrant city of Chicago, Illinois, in the year 1872. Her journey in the entertainment industry began in the 1890s, when she met Margaret Seddon in vaudeville. The two formed a dynamic double act, known as the "Pixilated Sisters", which marked the beginning of their successful partnership.
As her career progressed, McWade transitioned to film, initially under contract to the Edison Film Company. Her first film, "The Drama of Heyville", was released in 1914, starring Marc McDermott, and was directed by Ashley Miller. She later joined the Vitagraph Film Company, where she continued to appear in various films.
One of her most notable roles was that of Mrs. Challenger, alongside Wallace Beery as Professor Challenger, in the 1925 film "The Lost World", produced by the First-National Film Company. Throughout her career, McWade was often cast in minor roles in many talkies, until her final film before retiring, "It Should Happen to You", directed by George Cukor and starring Jack Lemmon and Judy Holliday.