Steven Robert Weber was born on March 4, 1961, in Queens, New York, to Fran Frankel, a nightclub singer, and Stuart Weber, a nightclub performer and Borscht Belt comic and manager. He began appearing in television commercials at an early age and later studied at the High School of the Performing Arts in New York and graduated from New York State University.
Weber worked a series of menial jobs during his early career, including custodian, elevator operator, and singing waiter. He earned his break on TV in a presentation of Mark Twain's stories and quickly made his film debut in the popular comedy The Flamingo Kid (1984).
He gained recognition for his roles in offbeat and prestigious productions on film and prime-time TV, including the soap opera As the World Turns (1956) and the miniseries The Kennedys of Massachusetts (1990). In 1990, he co-starred in the sitcom Wings (1990) with Tim Daly, playing the role of Brian Hackett, the looser and goofier half of the brotherly team who co-owned a one-plane, Nantucket-based airline.
Weber faced the prospect of being typecast as a lovable loser, but he countered this by taking on more serious roles during the show's off-season. He appeared in a series of thrillers, including Single White Female (1992) and The Temp (1993),and made a cameo in the highly acclaimed film Leaving Las Vegas (1995).
In the 1990s, Weber's flair for comedy shone in his role as Jonathan Harker in the critically acclaimed horror spoof Dracula: Dead and Loving It (1995). He also impressed audiences with his performance as the complex title character in the gay romantic film comedy Jeffrey (1995).
After "Wings" ended in 1997, Weber divorced his actress wife Finn Carter and married actress and TV executive Juliette Hohnen in 1995. They have two children, Jack and Alfie.
Weber has continued to work in television and film, appearing in a wide range of roles, including the TV-movie version of Stephen King's horror classic The Shining (1997),for which he earned a Saturn award. He has also appeared in the popular A.R. Gurney theater piece Love Letters (1999) alongside Laura Linney.
In addition to his work in film and television, Weber has had a successful stage career, appearing in a variety of productions, including the Broadway musical "The Producers" and the play "National Anthems" in London.
Weber has remained productive into the millennium, appearing in a range of films, including Sexual Life (2004),The Amateurs (2005),Inside Out (2005),and more recently, A Thousand Junkies (2017),The Perfection (2018),and Allan the Dog (2020).
He has also continued to work in television, appearing in a stream of comedic and dramatic recurring roles on shows such as "The D.A.," "Will & Grace," "Monk," "Law & Order: Special Victims Unit," "Desperate Housewives," and more.