The class of Nuke 'Em High returns to college, where the nuclear factory has been rebuilt and now includes a technology institute. The school's professor has created Sub-humanoids, living beings without emotions, programmed to perform tasks. A school reporter falls in love with a beautiful Sub-humanoid, but she has a tendency to spontaneously melt down.

Class of Nuke 'Em High Part II: Subhumanoid Meltdown
A student journalist teams up with a half-human, half-robot ally to thwart the sinister plans of a gargantuan, mutated squirrel threatening their educational institution.