In a transformed 2046 Earth, the town of Defiance, formerly St. Louis, thrives as a multicultural hub, with Nolan and Irisa at its core. They must navigate a complex web of relationships between leaders and residents, including powerful figures like Rafe McCawley, the Tarrs, and Mayor Amanda Rosewater.

A post-apocalyptic world ravaged by war, a father-daughter duo, Jeb Nolan and...