John Litel's on-screen persona of a tough, no-nonsense individual was not solely attributed to his acting abilities, as his real-life experiences had a significant impact on his performances. During World War I, Litel enlisted in the French army, eager to take action before the United States entered the conflict. His bravery was recognized on two occasions, as he received decorations for his valorous deeds.
Following the war, Litel returned to the United States and enrolled in the American Academy of Dramatic Arts. He subsequently embarked on a touring career with various stage companies, making his film debut in 1929.
In the 1930s, Litel became a part of the renowned "Warner Bros. Stock Company," a group of talented character actors that included notable performers such as Ward Bond, Frank McHugh, Joan Blondell, George Tobias, Henry O'Neill, and Alan Hale. Throughout his illustrious career, Litel appeared in numerous films, often portraying authority figures like tough police captains, hard-nosed district attorneys, and no-nonsense business executives.
In addition to his versatility as a character actor, Litel was also capable of convincingly playing villains, as exemplified by his portrayal of the nefarious "Scorpion" in the classic serial Don Winslow of the Navy (1942).
Throughout his remarkable career, Litel appeared in over 200 films, occasionally taking on leading roles but mostly serving as a supporting actor. From 1952 to 1953, he played the role of Robert Cummings' brooding boss, Mr. Thackery, in the NBC-TV sitcom My Hero (1952).