In a world where vampires exist, Blade seeks to eradicate all vampire evil. After saving Dr. Karen Jenson from a vampire attack, Blade takes her to his hideout to help her recover, alongside Abraham Whistler. However, the vampire Quinn, whom Blade defeated, reports back to his master Deacon Frost, who is planning a devastating surprise for humanity.

Blade
A half-vampire, half-human hybrid dedicates himself to defending humanity and ridding the world of malevolent vampires.